副研究员。

博士毕业于南方医科大学。任广东省精准应用学会类器官与器官芯片分会常务委员。主要研究方向为：结合皮肤类器官与病毒载体靶向递送技术，研究遗传性皮肤病的发病机制和基因治疗策略。主要学术业绩：（1）建立了人多能干细胞来源的人皮肤类器官3D分化平台，为遗传性皮肤病疾病模拟和致病机制研究提供工具；（2）构建了复制缺陷型HSV-1重组病毒和ZIKV包膜糖蛋白Env假病毒载体，为实现体内基因编辑和基因递送提供重要工具；（3）揭示了OSMR和CST6基因突变调控基底层角质形成细胞增殖与分化参与遗传角化性皮肤病的致病分子机制；阐明了前炎症因子肿瘤抑制素通过GSDME介导的焦亡调控角质形成细胞炎症发生的分子机制。目前，主持国家自然科学基金青年项目、博士后面上项目和广东省基础与应用基础研究基金各1项。以第一/通讯作者在Protein & Cell、Int J Biol Sci、Hum Gene Ther和J Dermatol Sci等杂志发表研究论文8篇，申请国家发明专利4项，授权2项。

代表性论文

(1) Liu H*, Qiu B*, Yang H*, Zheng W, Luo Y, Zhong Y, Lu P, Chen J, Luo Y, Liu J#, Yang B#. AHNAK, regulated by the OSM/OSMR signaling, involved in the development of primary localized cutaneous amyloidosis. J Dermatol Sci. 2023 May;110(2):53-60. doi: 10.1016/j.jdermsci.2023.04.004.

(2) Wang X*, Liu J*, Chen J, Xu X, Zhong Y, Xu Y, Lu P, Zhou J, Lin Z, Yang B#, Yang C#. Loss-of-function mutations in CST6 cause dry skin, desquamation and abnormal keratosis without hypotrichosis. Clin Genet. 2023 Mar;103(3):301-309. doi: 10.1111/cge.14265.

(3) Liu J*, Mao Y*, Li Q, Qiu Z, Li J, Li X, Liang W, Xu M, Li A, Cai X, Wu W, Chen H, Yan R, Li J, Gu W, Li H. Efficient Gene Transfer to Kidney Using a Lentiviral Vector Pseudotyped with Zika Virus Envelope Glycoprotein. Hum Gene Ther. 2022 Dec;33(23-24):1269-1278. doi: 10.1089/hum.2022.053.

(4) Zheng W*, Zhong Y*, Yuan L, Yu X, Wang X, Yang C, Liu H, Lv P, Luo Y, Qiu B, Liu J#, Yang B#. Generation of a human embryonic stem cell line (SMUDHe010-A-82) carrying a homozygous c.1538G > A (p.G513D) mutation in the OSMR gene by CRISPR/Cas9-mediated homologous recombination. Stem Cell Res. 2022 Aug;63:102842. doi: 10.1016/j.scr.2022.102842.

(5) Liu J*#, Zhong Y*, Liu H, Yang H, Lu P, Shi Y, Wang X, Zheng W, Yu X, Xu Y#, Yang B#. Oncostatin M sensitizes keratinocytes to UVB-induced inflammation via GSDME-mediated pyroptosis. J Dermatol Sci. 2021 Nov;104(2):95-103. doi: 10.1016/j.jdermsci.2021.09.004.

(6) Liu J*, Chen J*, Zhong Y, Yu X, Lu P, Feng J, Zhang X, Ma S, Yang C, Yang B#, Rong Z#. OSMRβ mutants enhance basal keratinocyte differentiation via inactivation of the STAT5/KLF7 axis in PLCA patients. Protein Cell. 2021 Aug;12(8):653-661. doi: 10.1007/s13238-020-00818-3.

(7) Liu J, Li Q, Li X, Qiu Z, Li A, Liang W, Chen H, Cai X, Chen X, Duan X, Li J, Wu W, Xu M, Mao Y, Chen H, Li J, Gu W#, Li H#. Zika Virus Envelope Protein induces G2/M Cell Cycle Arrest and Apoptosis via an Intrinsic Cell Death Signaling Pathway in Neuroendocrine PC12 Cells. Int J Biol Sci. 2018 Jun 8;14(9):1099-1108. doi: 10.7150/ijbs.26400.

(8) Liu J*, Wan P*, Li Q*, Li X, Li A, Chen H, Li J, Liang W, Zheng H#, Gu W#, Li H#. Construction and Identification of Recombinant HEK293T Cell Lines Expressing Non-structural Protein 1 of Zika Virus. Int J Med Sci. 2017 Sep 4;14(11):1072-1079. doi: 10.7150/ijms.20417.