研究方向是发育与干细胞计算系统生物学，长期致力于血液系统大数据分析研究，系统解析影响造血干细胞发育与分化的调控因素及血液系统疾病的致病机理。主要学术成绩：1）运用大数据分析技术系统解析RNA结合蛋白、可变剪切和自噬在造血干细胞发生中的调控新机制，阐明粒/单谱系分化及命运决定的调控机制；2）围绕RNA定位、互作与功能开发血液系统大数据资源平台与算法工具；3）利用血液系统大数据资源平台与算法工具系统解析骨髓增殖性肿瘤致病机理。近年来以通讯作者（含共同）在Cell Stem Cell、Nucleic Acids Res、Sci Adv、Nat Commun、EMBO J、Autophagy和Brief Bioinform等主流期刊发表代表性论文45篇，总被引用3000余次，ESI高被引论文10篇。主持国家自然科学基金课题3项，参与国家重点研发计划发育编程及其代谢调节专项2项。担任中国生物信息学会（筹）系统生物学专委会常务委员，中国生理学会血液生理学专委会委员和中国计算机学会生物信息学专业委员会委员。

代表性论文

1. Tianyuan Liu, Bohao Zou, Manman He, Yongfei Hu, Yiying Dou, Tianyu Cui, Puwen Tan, Shaobin Li, Shuan Rao, Yan Huang, Sixi Liu*, Kaican Cai*, Dong Wang*. LncReader: identification of dual functional long noncoding RNAs using a multi-head self-attention mechanism. Briefings in Bioinformatics.2023. 24(1):bbac579. 

2. Jia Chen, Jiahao Lin, Yongfei Hu, Meijun Ye, Linhui Yao, Le Wu, Wenhai Zhang, Meiyi Wang, Tingting Deng, Feng Guo, Yan Huang, Bofeng Zhu*, Dong Wang*. RNADisease v4.0: an updated resource of RNA-associated diseases, providing RNA-disease analysis, enrichment and prediction. Nucleic Acids Research. 2023. 51(D1):D1397-D1404. 

3. Fang Wang, Puwen Tan, Pengcheng Zhang, Yue Ren, Jie Zhou, Yunqiao Li, Siyuan Hou, Shuaili Li, Linlin Zhang, Yanni Ma, Chaojie Wang, Wanbo Tang, Xiaoshuang Wang, Yue Huo, Yongfei Hu, Tianyu Cui, Chao Niu, Dong Wang*, Bing Liu*, Yu Lan*, Jia Yu*. Single-cell architecture and functional requirement of alternative splicing during hematopoietic stem cell formation. Science Advances. 2022. 8(1):eabg5369. 

4. Tianyu Cui, Yiying Dou, Puwen Tan, Zhen Ni, Tianyuan Liu, DuoLin Wang, Yan Huang, Kaican Cai, Xiaoyang Zhao, Dong Xu*, Hao Lin*, Dong Wang*. RNALocate v2.0: an updated resource for RNA subcellular localization with increased coverage and annotation. Nucleic Acids Research. 2022. 50(D1):D333-D339. 

5. Jingyuan Tong#, Ting Sun#, Shihui Ma#, Yanhong Zhao#, Mankai Ju#, Yuchen Gao, Ping Zhu, Puwen Tan, Rongfeng Fu, Anqi Zhang, Ding Wang, Di Wang, Zhijian Xiao, Jiaxi Zhou, Renchi Yang, Stephen Loughran, Juan Li, Anthony R. Green, Emery H. Bresnick, Dong Wang*, Tao Cheng*, Lei Zhang*, Lihong Shi*. Hematopoietic stem cell heterogeneity is linked to the initiation and therapeutic response of myeloproliferative neoplasms. Cell Stem Cell. 2021. 28(3):502-513. 

6. Yang Zhang#, Tianyuan Liu#, Jing Wang#, Bohao Zou#, Le Li, Linhui Yao, Kechen Chen, Lin Ning, Bingyi Wu*, Xiaoyang Zhao*, Dong Wang*. Cellinker: a platform of ligand-receptor interactions for intercellular communication analysis. Bioinformatics. 2021. 37(14):2025–2032. 

7. Yang Zhang#,*, Tianyuan Liu#, Xuesong Hu#, Mei Wang, Jing Wang, Bohao Zou, Puwen Tan, Tianyu Cui, Yiying Dou, Lin Ning, Yan huang, Shuan Rao, Dong Wang*, Xiaoyang Zhao*. CellCall: integrating paired ligand-receptor and transcription factor activities for cell-cell communication. Nucleic Acids Research. 2021. 49(15):8520-8534. 

8. Duolin Wang, Zhaoyue Zhang, Yuexu Jiang, Ziting Mao, Dong Wang*, Hao Lin*, Dong Xu*. DM3Loc: Multi-label mRNA Subcellular Localization Prediction and Analysis Based on Multi-head Self-attention Mechanism. Nucleic Acids Research. 2021. 49(8):e46. 

9. Yunqing Lin#, Tianyuan Liu#, Tianyu Cui#, Zhao Wang, Yuncong Zhang, Puwen Tan, Yan Huang, Jia Yu, Dong Wang*. RNAInter in 2020: RNA interactome repository with increased coverage and annotation. Nucleic Acids Research. 2020. 48(D1):D189-197. 

10. Yongfei Hu#, Yan Huang#, Ying Yi, Hongwei Wang, Bing Liu*, Jia Yu*, Dong Wang*. Single-cell RNA sequencing highlights transcription activity of autophagy-related genes during haematopoietic stem cell formation in mouse embryos. Autophagy. 2017. 13(4): 770-771.