个人简介
自1995年起，从事性传播疾病病原生物学与防控技术研究。2000年荷兰阿姆斯特丹大学，2014年美国Duke大学、北卡大学访问学者。先后主持国自然等科研课题23项，主持国自然等科研课题23项，获得省市级科研成果6项，主编参编著作及国家行标等8部，在等国内外期刊发表论文200余篇。
中国性病艾滋病防治协会理事，中国麻风病防治协会皮肤性病检验与诊断分会副主委，中华医学会微生物学与免疫学特殊病原体组常委；广东省性病艾滋病防治协会副会长，广东省性病实验专家委员会主任，广东省医学会检验分会常委，广东省医师学会检验分会常委，美国北卡大学全球健康兼职教授。
研究领域
1. 性病病原体分子流行病学与分子诊断技术开发
2. 性病病原体的耐药与耐药机理研究
3. 性病病原体的致病性与致病机理研究
个人成果
1. Wentao Chen, Hao Luo, Lihong Zeng, Yuying Pan, Jonathan B. Parr, Yinbo Jiang, Clark H. Cunningham, Kelly L. Hawley, Justin D. Radolf, Wujian Ke, Jiangli Ou, Jianjiang Yang, Bin Yang,* Heping Zheng* A suite of PCR-LwCas13a assays for detection and genotyping of Treponema pallidum in clinical samples. Nature Communications. 2022. 13:4671
2. Xiaomian Lin, Wentao Chen, Qinghui Xie, Yuqi Yu, Yiwen Liao, Zhanjin Feng, Xiaolin Qin, Xingzhong Wu, Sanmei Tang & Heping Zheng*. Dissemination and genome analysis of high-level ceftriaxone-resistant penA 60.001 Neisseriagonorrhoeae strains from the Guangdong Gonococcal antibiotics susceptibility Programme (GD-GASP), 2016–2019, Emerging Microbes & Infections. 2022. 11:1, 344-350
3. Chen W, Šmajs D, Hu Y, Ke W, Pospíšilová P, Hawley KL, Caimano MJ, Radolf JD, Sena A, Tucker JD, Yang B, Juliano JJ, Zheng H*, Parr JB*. Analysis of Treponema pallidum Strains From China Using Improved Methods for Whole-Genome Sequencing From Primary Syphilis Chancres. J Infect Dis. 2021. 3;223(5):848-853.
4. Xiaomian Lin, Xiaolin Qin, Xingzhong Wu, Yiwen Liao, Yuqi Yu, Qinghui Xie, Sanmei Tang, Chixing Guo, Junming Pei, Zhizhou Wu, Changhui Cai, Feng Wang, Shanghua Wu, Heyong Chen, Xiaofeng Liu, Ming Li, Wenling Cao, Heping Zheng*. Markedly Increasing Antibiotic Resistance and Dual Treatment of Neisseria gonorrhoeae Isolates in Guangdong, China, from 2013 to 2020. Antimicrobial Agents and Chemotherapy . 2022 29;e0229421.
5. Lin X, Chen W, Yu Y, Lan Y, Xie Q, Liao Y, Wu X, Tang S, Qin X, Heping Zheng*. Emergence and Genomic Characterization of Neisseria gonorrhoeae Isolates with High Levels of Ceftriaxone and Azithromycin Resistance in Guangdong, China, from 2016 to 2019. 2022 Dec 21;10(6):e0157022.
6. Hao Luo , Wentao Chen , Zhida Mai , Jianjiang Yang , Xiaomian Lin , Lihong Zeng , Yuying Pan , Qinghui Xie , Qingqing Xu, Xiaoxiao Li , Yiwen Liao, Zhanqin Feng , Jiangli Ou , Xiaolin Qin , Heping Zheng*. Development and application of Cas13a-based diagnostic assay for Neisseria gonorrhoeae detection and azithromycin resistance identification. J Antimicrob Chemother 2022 23;77(3):656-664.
7. Xueying Yu, Qingqing Xu, Wentao Chen, Zhida Mai, Lijun Mo, Xin Su, Jiangli Ou, Yinyuan Lan, Heping Zheng*and Yaohua Xue* Rhein inhibits Chlamydia trachomatis infection by regulating pathogen-host cell。 Frontier in Public Health. 2022. 26;10:1002029
8. Xue Y, Chen W, Mai Z, Yu X, Wu Q, Wan C, Su X, Wu Y, Rong Z, Zheng H*. Inhibition of the Extracellular Signal-Regulated Kinase/Ribosomal S6 Kinase Cascade Limits Chlamydia trachomatis Infection. J Invest Dermatol. 2021 141(4):852-862.
9. Yang J, Huang T, Zhao P, Lin X, Feng Z, Senhong Chen, Xue Y, Chen W, Zhao Y, Yang B*, Zheng H*. MicroRNA-101-3p, MicroRNA-195-5p, and MicroRNA-223-3p in Peripheral Blood Mononuclear Cells May Serve as Novel Biomarkers for Syphilis Diagnosis. Microb Pathog. 2021. 152:104769.
10. Su X#, Qin X#, Chen W, Yu X, Liao Y, Xu Q, Xue Y, Huang J*, Zheng H*. Performance of Sexually Transmitted Disease Laboratories for Chlamydia trachomatis Detection in Guangdong, China. Sex Transm Dis. 2021. 1;48(8):523-528.
11. Huang T#, Yang J#, Zhang J, Ke W, Zou F, Wan C, Wang L, Zhang X, Liang F, Mei S, Zhang Q, Rong Z, Yang B*, Zheng H*. MicroRNA-101-3p Downregulates TLR2 Expression, Leading to Reduction in Cytokine Production by Treponema pallidum-Stimulated Macrophages. J Invest Dermatol. 2020. 140(8):1566-1575.
12. Shao-Chun Chen, Jing-Wei Liu, Xing-ZhongWu, Wen-Ling Cao, FengWang, Jin-Mei Huang, Yan Han, Xiao-Yu Zhu, Bang-Yong Zhu, Quan Gan, Xiao-Zheng Tang, Xing Shen, Xiao-Lin Qin, Yu-Qi Yu, He-Ping Zheng*, Yue-Ping Yin. Comparison of Microdilution Method with Agar Dilution Method for Antibiotic Susceptibility Test of Neisseria gonorrhoeae. Infection and Drug Resistance. 2020:13 1775–1780.
13. Ke W#, Li D#, Tso LS, Wei R, Lan Y, Chen Z, Zhang X, Wang L, Liang C, Liao Y, Chen H, Liu Y, Zheng H*, Yang L*. Macrolide and fluoroquinolone associated mutations in Mycoplasma genitalium in a retrospective study of male and female patients seeking care at a STI Clinic in Guangzhou, China, 2016-2018. BMC Infect Dis. 2020. 20(1):950.
14. Huang T, Zhang J, Ke W, Zhang X, Chen W, Yang J, Liao Y, Liang F, Mei S, Li M, Luo Z, Zhang Q, Yang B, Zheng H*. MicroRNA expression profiling of peripheral blood mononuclear cells associated with syphilis. BMC Infect Dis. 2020 ; 20(1):165.
15. Lu Y, Ke W, Yang L, Wang Z, Lv P, Gu J, Hao C, Li J, Cai Y, Gu M, Liu H, Chen W, Zhang X, Wang L, Liu Y, Yang B, Zou H, Zheng H*. Clinical prediction and diagnosis of neurosyphilis in HIV-negative patients: a case-control study. BMC Infect Dis. 2019 Dec 2;19(1):1017.
16. Wang C, Tang W, Zhao P, Tucker J, Chen L, Smith MK, Wong NS, Dong W, Yang B, Zheng H*. Rapid increase of gonorrhoea cases in Guangdong Province, China, 2014-2017: a review of surveillance data. BMJ Open. 2019;9:e031578.
17. Qin X#, Zhao Y#, Chen W, Wu X, Tang S, Li G, Yuqi Y, Cao W, Liu X, Huang J, Yang J, Chen W, Tang W*, Zheng H*. Changing antimicrobial susceptibility and molecular characterisation of Neisseria gonorrhoeae isolates in Guangdong, China: in a background of rapidly rising epidemic. Int J Antimicrob Agents. 2019; 54(6):757-765.
18. Zhao YH#, Qin XL#, Yang JY, Liao YW, Wu XZ, Zheng H*. Identification and expression analysis of ceftriaxone resistance-related genes in Neisseria gonorrhoeae integrating RNA-Seq data and qRT-PCR validation. J Glob Antimicrob Resist. 2018,pii: S2213-7165(18)30197-8.
19. Wu X#, Qin X#, Huang J, Wang F, Li M, Wu Z, Liu X, Pei J, Wu S, Chen H, Guo C, Xue Y, Tang S, Fang M, Lan Y, Ou J, Xie Z, Yu Y, Yang J, Chen W, Zhao Y, Zheng H*. Determining the in vitro susceptibility of Neisseria gonorrhoeae isolates from 8 cities in Guangdong Province through an improved microdilution method. Diagn Microbiol Infect Dis. 2018, 92(4):325-331.